BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
نویسندگان
چکیده
منابع مشابه
Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
Mammalian cells are frequently at risk of DNA damage from both endogenous and exogenous sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor and assure the integrity of their genome. In cells, the intact and effective DDR is essential for the maintenance of genomic stability and it acts as a critical barrier to suppress the development of cancer in humans. ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2006
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2006.07.002